Pharmacokinetic interactions of artemether and pyrimethamine in healthy male Thais.
Southeast Asian J Trop Med Public Health
;
1998 Mar; 29(1): 18-23
Article
in English
| IMSEAR
| ID: sea-34206
ABSTRACT
The pharmacokinetics of a single oral dose of artemether (300 mg) and pyrimethamine (100 mg) given as each individual drug alone or as a drug combination (artemether 300 mg plus pyrimethamine 100 mg), were investigated in 8 healthy male Thai volunteers. Both artemether and pyrimethamine were rapidly absorbed after oral administration. Elimination of pyrimethamine was however, a relatively slow process compared with artemether, and thus resulted in a long terminal phase elimination half-life (50-106 hours). Pharmacokinetics of artemether and dihydroartemisinin following a single oral dose of artemether alone or in combination with pyrimethamine were similar. In contrast, coadministration of artemether resulted in significantly increased Cmax (medians of 818 vs 1,180 ng/ml) and contracted the apparent volume of distribution (medians of 3 vs 2.56 l/kg) of pyrimethamine.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pyrimethamine
/
Sesquiterpenes
/
Thailand
/
Humans
/
Male
/
Cross-Over Studies
/
Adult
/
Artemisinins
/
Drug Interactions
/
Antimalarials
Type of study:
Controlled clinical trial
Country/Region as subject:
Asia
Language:
English
Journal:
Southeast Asian J Trop Med Public Health
Year:
1998
Type:
Article
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