Detection through screening of maternal thyrotoxicosis induced central hypothyroidism in newborns.

Joseph, Roy; Lee, Yung Seng; Ng, Steven Chin Yuen; Loke, Kah Yin

Joseph, Roy; Lee, Yung Seng; Ng, Steven Chin Yuen; Loke, Kah Yin.

Southeast Asian J Trop Med Public Health ; 2003 ; 34 Suppl 3(): 150-1

Article in English | IMSEAR | ID: sea-34279

ABSTRACT

ABSTRACT

Use of a third generation TSH assay enabled extremely low values of TSH to be detected through newborn screening. The use of a supplemental free thyroxine improved testing specificity. The hypothyroidism observed is believed to be secondary to suppression of the hypothalamic-pituitary-thyroid axis by placentally transferred maternal thyroxine.

Subject(s)

Congenital Hypothyroidism; Female; Fetal Blood; Hematologic Tests; Humans; Hypothyroidism/diagnosis; Infant, Newborn; Infectious Disease Transmission, Vertical/prevention & control; Neonatal Screening/methods; Pregnancy; Pregnancy Complications/blood; Sensitivity and Specificity; Thyrotoxicosis/blood; Thyrotropin/blood; Thyroxine/administration & dosage

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Pregnancy Complications / Thyroxine / Thyrotoxicosis / Female / Humans / Infant, Newborn / Pregnancy / Thyrotropin / Sensitivity and Specificity / Neonatal Screening Type of study: Diagnostic study / Screening study Language: English Journal: Southeast Asian J Trop Med Public Health Year: 2003 Type: Article

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