Peripheral gangrene in nonfatal pediatric cerebral malaria: a report of two cases.
Southeast Asian J Trop Med Public Health
;
1991 Jun; 22(2): 190-4
Article
in English
| IMSEAR
| ID: sea-34372
ABSTRACT
Two Thai girls aged 10 and 13 years from the same rural area were admitted to Paholpolpayuhasena Hospital, Kanchanaburi, Thailand during the rainy season of 1989 with cerebral malaria. After several days of conventional treatment, both developed gangrene involving the feet and toes, but the lesions healed and no other complications were seen. In the absence of convincing clinical and laboratory evidence of vasculitis or coagulopathy, it seems likely that host factors (dehydration, sluggish peripheral circulation, platelet activation, subclinical intravascular coagulation) combined with strain-specific parasite factors (tissue sequestration of mature forms, rosette formation) may predispose to peripheral microvascular occlusion sufficient to produce infarction of tissue in susceptible children. However, despite the apparently ominous appearance of such lesions in a comatose child, the prognosis seems good.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Quinine
/
Female
/
Humans
/
Toes
/
Child
/
Adolescent
/
Malaria, Falciparum
/
Malaria, Cerebral
/
Foot
/
Foot Diseases
Type of study:
Prognostic study
Language:
English
Journal:
Southeast Asian J Trop Med Public Health
Year:
1991
Type:
Article
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