Identification of hemoglobin AC heterozygote status in a Malay family: a decision between hemoglobin electrophoresis and high performance liquid chromotography.
Southeast Asian J Trop Med Public Health
;
2007 May; 38(3): 543-5
Article
in English
| IMSEAR
| ID: sea-34452
ABSTRACT
Thalassemia is a common public health problem among Malays. Hemoglobin C (Hb C) is a hemoglobin beta variant resulting from a single base mutation at the 6th position of the beta-globin gene leading to the substitution of glycine for glutamic acid. Hb C is commonly detected in West Africans and in African American but has not been reported in Malaysia. It can be falsely diagnosed as HbE trait in the Malaysian Thalassemia Screening Program which utilizes cellulose acetate hemoglobin electrophoresis. This is the first reported case of Hb AC heterozygote status in a Malay family, with unusual splenomegaly in one of the family members.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Thalassemia
/
Female
/
Humans
/
Hemoglobins, Abnormal
/
Family
/
Child
/
Chromatography, High Pressure Liquid
/
Decision Making
/
Electrophoresis, Cellulose Acetate
/
Malaysia
Type of study:
Prognostic study
Country/Region as subject:
Asia
Language:
English
Journal:
Southeast Asian J Trop Med Public Health
Year:
2007
Type:
Article
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