Liver collagen in Opisthorchis viverrini infected hamsters following praziquantel treatment.
Southeast Asian J Trop Med Public Health
;
1983 Sep; 14(3): 290-3
Article
in English
| IMSEAR
| ID: sea-34491
ABSTRACT
The dose of praziquantel required to achieve a 100% worm reduction in O. viverrini infected hamsters was found to be 300 mg/kg body weight. The drug was administered orally for 1 day by dividing a total dose into 3 equal doses at 4 h interval. The effect of praziquantel treatment on liver collagen was followed by measuring liver collagen content in at various intervals after administration of the drug. A decrease in collagen content in the infected livers occurred within a few weeks following the treatment suggesting a recovery from liver fibrosis.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Opisthorchiasis
/
Praziquantel
/
Collagen
/
Cricetinae
/
Dose-Response Relationship, Drug
/
Isoquinolines
/
Liver
/
Animals
Language:
English
Journal:
Southeast Asian J Trop Med Public Health
Year:
1983
Type:
Article
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