Your browser doesn't support javascript.
loading
PCR can help early diagnosis of pulmonary tuberculosis.
Southeast Asian J Trop Med Public Health ; 2003 Mar; 34(1): 147-53
Article in English | IMSEAR | ID: sea-34760
ABSTRACT
One hundred and fifty-one patients, clinically suspected for pulmonary tuberculosis (age 31 +/- 13 years, male/female 112/39), were investigated to evaluate the diagnostic potential of polymerase chain reaction (PCR) based detection of the Mycobacterium tuberculosis complex in sputum. The diagnostic efficacy of PCR was compared with culture of Mycobacterium tuberculosis on egg-based Lowenstein-Jensen modified medium. PCR detected 71.5% (108/151), whereas culture detected 66.2% (100/151) of the clinically suspected patients. There was a significant association between the results of PCR and culture (chi2 = 59.524, p < 0.001). However, 23.2% (35/151) samples were found negative in both culture and PCR. Considering culture as the gold standard, the sensitivity of the PCR was 92%. and its specificity 70%. This lower apparent specificity may be due to the higher sensitivity of PCR.
Subject(s)
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Sputum / Tuberculosis, Pulmonary / Aged, 80 and over / Aged / Female / Humans / Male / Chi-Square Distribution / Polymerase Chain Reaction / Sensitivity and Specificity Type of study: Diagnostic study / Screening study Limits: Aged80 Language: English Journal: Southeast Asian J Trop Med Public Health Year: 2003 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: IMSEAR (South-East Asia) Main subject: Sputum / Tuberculosis, Pulmonary / Aged, 80 and over / Aged / Female / Humans / Male / Chi-Square Distribution / Polymerase Chain Reaction / Sensitivity and Specificity Type of study: Diagnostic study / Screening study Limits: Aged80 Language: English Journal: Southeast Asian J Trop Med Public Health Year: 2003 Type: Article