High mast cell density associated with granulomatous formation in tuberculous lymphadenitis.
Southeast Asian J Trop Med Public Health
;
2007 Jan; 38(1): 115-9
Article
in English
| IMSEAR
| ID: sea-34846
ABSTRACT
Mast cells are one of the main inflammatory cells involved in the pathogenesis of tuberculosis. Previous reports revealed that mast cells participated in both acute and chronic states of infection with Mycobacterium tuberculosis through direct contact or indirect enhancement by releasing mediators. The authors evaluated mast cell density on tissue sections of tuberculous lymphadenitis stained with 0.1% toluidine blue from 45 cases, all of which were retrieved from the surgical pathology files of King Chulalongkorn Memorial Hospital from 1999 to 2006. A number of mast cells were correlated semiquantitatively with granulomas which were formed by aggregation of epithelioid histiocytes, multinucleated giant cells, and caseous necrosis. We found that mast cell density was significantly increased in lymph nodes with greater granuloma involvement (p = 0.030) and multinucleated giant cell formation (p = 0.010). These findings indicate a significant correlation between mast cell density and the granulomatous formation responsible for M. tuberculosis.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Thailand
/
Tolonium Chloride
/
Tuberculosis, Lymph Node
/
Female
/
Humans
/
Male
/
Cell Count
/
Adult
/
Granuloma
/
Mast Cells
Country/Region as subject:
Asia
Language:
English
Journal:
Southeast Asian J Trop Med Public Health
Year:
2007
Type:
Article
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