In vitro activity of fosfomycin-gentamicin, fosfomycin-ceftazidime, fosfomycin-imipenem and ceftazidime-gentamicin combinations against ceftazidime-resistant Pseudomonas aeruginosa.
Southeast Asian J Trop Med Public Health
;
2005 Sep; 36(5): 1239-42
Article
in English
| IMSEAR
| ID: sea-34899
ABSTRACT
The effects of antimicrobial combinations against ceftazidime-resistant Pseudomonas aeruginosa strains isolated from hospitalized patients were investigated. Using the checkerboard titration method, combination of fosfomycin-gentamicin, fosfomycin-ceftazidime, fosfomycin-imipenem and ceftazidime-gentamicin was synergistic against 4, 11, 38 and 39% of 22, 18, 29 and 18 strains tested respectively and additive effect of the combinations against the strains tested was 41, 33, 14 and 44%, respectively. Antagonistic effects against the isolates were noted when fosfomycin was combined with gentamicin (27%), ceftazidime (22%) and imipenem (7%). No antagonistic effect was observed in the ceftazidime-gentamicin combination.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pseudomonas aeruginosa
/
Thailand
/
Humans
/
Gentamicins
/
Microbial Sensitivity Tests
/
Ceftazidime
/
Imipenem
/
Drug Resistance, Bacterial
/
Drug Therapy, Combination
/
Fosfomycin
Country/Region as subject:
Asia
Language:
English
Journal:
Southeast Asian J Trop Med Public Health
Year:
2005
Type:
Article
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