Clinical, hematological and molecular features in Thais with beta-Malay/beta-thalassemia and beta-Malay/HbE.
Southeast Asian J Trop Med Public Health
;
1997 ; 28 Suppl 3(): 106-9
Article
in English
| IMSEAR
| ID: sea-35020
ABSTRACT
A total of 50 patients and relatives were studied comprising 12 cases of compound heterozygosity of beta-Malay and beta + thalassemia, 10 cases of compound heterozygosity of beta-Malay and beta degree thalassemia, 10 cases of beta-Malay and HbE and 18 cases of beta-Malay heterozygosity. Patients with beta-Malay and HbE had very mild clinical symptoms or were asymptomatic of thalassemia disease in the absence of blood transfusion. Homozygosity of beta-Malay produce mild clinical symptoms of thalassemic disease with normal facial characteristics and were not transfusion dependent. Patients with beta-Malay and IVS 1 nt 5 (G-C) had severe clinical symptoms, and were transfusion dependent. Patients with beta-Malay and beta degree thalassemia had severe clinical symptoms, delayed weight and height in relation to age, were transfusion dependent and had classical features of thalassemic diseases.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Thailand
/
Blood Transfusion
/
Humans
/
Hemoglobin E
/
Hemoglobins, Abnormal
/
Beta-Thalassemia
/
Heterozygote
/
Homozygote
Country/Region as subject:
Asia
Language:
English
Journal:
Southeast Asian J Trop Med Public Health
Year:
1997
Type:
Article
Similar
MEDLINE
...
LILACS
LIS