The absence of antagonism between extracts of Clinacanthus nutans Burm. and Naja naja siamensis venom.
Southeast Asian J Trop Med Public Health
;
1977 Jun; 8(2): 249-54
Article
in English
| IMSEAR
| ID: sea-35205
ABSTRACT
Clinacanthus nutans Burm, a herb reputed in Thailand and Malaysia to be "snakebite antidote" has been tested in vitro and in vivo for antivenin activity. The aqueous extract of C. nutans leaves has been found to have no effect on the inhibition of neuromuscular transmission produced by purified Naja naja siamensis neurotoxin in isolated rat phrenic-nerve diaphragm preparations. The extract of C. nutans, when given orally or intraperitoneally, are ineffective in prolonging the survival time of experimental mice receiving lethal doses of N.n. siamensis crude venom. Oral administrations of the herb extracts pretreated with alpha-amylase or beta-amylase also fail to protect the animal. It is concluded that the extract of C. nutans can not antagonize the action of cobra venom.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Phrenic Nerve
/
Rats
/
Snake Bites
/
Plant Extracts
/
Administration, Oral
/
Cobra Neurotoxin Proteins
/
Synaptic Transmission
/
Elapid Venoms
/
Amylases
/
Injections, Intraperitoneal
Language:
English
Journal:
Southeast Asian J Trop Med Public Health
Year:
1977
Type:
Article
Similar
MEDLINE
...
LILACS
LIS