Human immunodeficiency virus type 1 subtypes among Malaysian intravenous drug users.
Southeast Asian J Trop Med Public Health
;
2000 Jun; 31(2): 283-6
Article
in English
| IMSEAR
| ID: sea-35282
ABSTRACT
The HIV-1 genetic variation in 60 infected Malaysian intravenous drug users (IDU) was studied by comparison of the nucleotide sequences and their predicted amino acid sequences in the V3 loop of the external glycoprotein gp120. In this study, HIV-1 B, C and E subtypes were identified among Malaysian IDU, with HIV-1 B being the predominant subtype (91.7%). HIV-1 C and HIV-1 E were minority subtypes among Malaysian IDU. Analysis of the amino acid alignment of the C2-V3 region of the env gene suggests a genetic relationship between Thai and Malaysian B and E subtype strains. This study serves as a baseline for monitoring HIV-1 genetic diversity and spread in Malaysia.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Peptide Fragments
/
Phylogeny
/
Genetic Variation
/
Humans
/
Male
/
Molecular Sequence Data
/
Base Sequence
/
HIV Envelope Protein gp120
/
HIV Infections
/
Substance Abuse, Intravenous
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Country/Region as subject:
Asia
Language:
English
Journal:
Southeast Asian J Trop Med Public Health
Year:
2000
Type:
Article
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