Comparative trial on the response of Plasmodium falciparum to halofantrine and mefloquine in Trat Province, eastern Thailand.

Ketrangsee, S; Vijaykadga, S; Yamokgul, P; Jatapadma, S; Thimasarn, K; Rooney, W

Ketrangsee, S; Vijaykadga, S; Yamokgul, P; Jatapadma, S; Thimasarn, K; Rooney, W.

Southeast Asian J Trop Med Public Health ; 1992 Mar; 23(1): 55-8

Article in English | IMSEAR | ID: sea-35390

ABSTRACT

ABSTRACT

With the appearance of strains of Plasmodium falciparum in the Trat Province, eastern Thailand, reported to have developed resistance to mefloquine there is a need for an alternative drug. This comparative trial with mefloquine and halofantrine has demonstrated extremely low cure rates with both drugs (33.3% and 28.13% respectively), cross-resistance is suggested.

Subject(s)

Administration, Oral; Adult; Antimalarials/administration & dosage; Drug Resistance; Female; Humans; Malaria, Falciparum/drug therapy; Male; Mefloquine/administration & dosage; Phenanthrenes/administration & dosage; Thailand/epidemiology; Treatment Outcome

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Phenanthrenes / Thailand / Female / Humans / Male / Drug Resistance / Mefloquine / Administration, Oral / Treatment Outcome / Malaria, Falciparum Country/Region as subject: Asia Language: English Journal: Southeast Asian J Trop Med Public Health Year: 1992 Type: Article

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