Immune responses following killed whole vibrio-B subunit oral cholera vaccine in human volunteers.
Southeast Asian J Trop Med Public Health
;
1989 Jun; 20(2): 201-5
Article
in English
| IMSEAR
| ID: sea-35826
ABSTRACT
Immunogenicity of killed whole vibrio and B subunit oral cholera vaccines in American and Thai volunteers were analysed in terms of significant rise of antibody titre. Three doses of 2 x 10(11) killed vibrios and 5 mg of cholera toxin B subunit were given at two-week intervals. There were no differences in the percent of volunteers with significant rise of serum immunoglobulin G and secretory immunoglobulin A (sIgA) to cholera toxin. However, the percent with significant rises of serum antibody to whole cell V. cholerae Inaba measured by vibriocidal titre and serum immunoglobulin G, and secretory immunoglobulin A to lipopolysaccharide (LPS) measured by ELISA in American volunteers were significantly different from those in Thai volunteers (89% VS 45%, 68% VS 9% and 53% VS 0%, respectively) (p less than 0.05).
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Bangladesh
/
Humans
/
Immunoglobulin G
/
Cholera Vaccines
/
Vaccines, Inactivated
/
Cholera
/
Administration, Oral
/
Adult
/
Antibodies, Bacterial
Country/Region as subject:
Asia
Language:
English
Journal:
Southeast Asian J Trop Med Public Health
Year:
1989
Type:
Article
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