Comparison of effects of pyronaridine, amodiaquine, mefloquine and qinghaosu on rodent malaria.
Southeast Asian J Trop Med Public Health
;
1992 Mar; 23(1): 59-63
Article
in English
| IMSEAR
| ID: sea-36394
ABSTRACT
Blood schizontocidal effect of antimalarials were compared by 4-day suppressive test with an extended observation period of 31 days. On a drug-sensitive Plasmodium berghei ANKA strain, pyronaridine (PND) exhibited the best effect, followed by amodiaquine (ADQ), mefloquine (MFQ), and qinghaosu (QHS). On a moderately chloroquine-resistant P. berghei NS line, the order of effects was the same, PND greater than ADQ greater than MFQ greater than QHS. On a highly pyronaridine-resistant P. berghei RP line, ADQ, MFQ and QHS showed cross resistance with PND.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Plasmodium berghei
/
Sesquiterpenes
/
Female
/
Male
/
Drug Resistance
/
Drug Administration Schedule
/
Mefloquine
/
Artemisinins
/
Drug Evaluation, Preclinical
/
Amodiaquine
Language:
English
Journal:
Southeast Asian J Trop Med Public Health
Year:
1992
Type:
Article
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