Enhanced maturation and proliferation of beta-thalassemia/Hb E erythroid precursor cells in culture.
Southeast Asian J Trop Med Public Health
;
2005 Sep; 36(5): 1298-303
Article
in English
| IMSEAR
| ID: sea-36422
ABSTRACT
Upon erythroid cell maturation in vivo, beta-thalassemic erythroid cells accumulate unmatched unstable alpha-globin chains that are believed to be a causal factor in such cell destruction. This study showed that beta-thalassemia/Hb E erythroid precursor cells from peripheral blood had accelerated maturation, and could mature to the terminal erythroid stage. During the early period of cell culture, erythroid precursor cells derived from subjects with the more severe form of beta-thalassemia/Hb E had higher rate of erythroid maturation. In addition, peripheral blood mononuclear cells from beta-thalassemia/Hb E subjects had higher erythroid proliferative potential than cells derived from normal controls. Erythroid proportion in the more severe beta-thalassemia/Hb E cases was less than that of the milder cases. Premature apoptosis was not observed during the 15 days of erythroid cell culture from both beta-thalassemia/Hb E and normal subjects.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Thailand
/
Female
/
Humans
/
Male
/
Erythroid Precursor Cells
/
Child
/
Child, Preschool
/
Adolescent
/
Beta-Thalassemia
/
Cell Culture Techniques
Country/Region as subject:
Asia
Language:
English
Journal:
Southeast Asian J Trop Med Public Health
Year:
2005
Type:
Article
Similar
MEDLINE
...
LILACS
LIS