Antineutrophil cytoplasmic antibody (ANCA) and rapidly progressive crescentic glomerulonephritis in Thai population.
Asian Pac J Allergy Immunol
;
1999 Dec; 17(4): 281-7
Article
in English
| IMSEAR
| ID: sea-36475
ABSTRACT
The impact of vasculitis as a cause of primary rapidly progressive crescentic glomerulonephritis (RPGN) was examined in patients with Thai ethnic by antineutrophil cytoplasmic antibody (ANCA) test. Thirty patients found in a six years study period were included. Patients' mean age was 34.8+/-16.4 years. Mean crescent score was 86.2+/-22.9%. ANCA proved positive in fifteen patients. This helps to differentiate vasculitis associated (ANCA positive) from nonvasculitis (ANCA negative) RPGN. Incidence of immune complex type RPGN (46.6%) is higher than the Caucasians while the incidence of antiglomerular basement membrane antibody (anti-GBM disease) is much lower. More vasculitis patients were treated with cyclophosphamide (n = 11) than the nonvasculitis group (n = 2). Mean renal survival time of ANCA and non-ANCA associated patients were 26.69 and 14.16 months, respectively. Renal survival of all patients is significantly worse if associated with a high entry creatinine (>6 mg/dl). Our results show that vasculitis associated RPGN is not an uncommon disease in the Thai population and can be recognized initially by ANCA test.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Thailand
/
Vasculitis
/
Female
/
Humans
/
Male
/
Survival Analysis
/
Follow-Up Studies
/
Disease Progression
/
Fluorescent Antibody Technique, Indirect
/
Antibodies, Antineutrophil Cytoplasmic
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Country/Region as subject:
Asia
Language:
English
Journal:
Asian Pac J Allergy Immunol
Year:
1999
Type:
Article
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