Cell-mediated immune response following intracutaneous immunisation with human diploid cell rabies vaccine.
Asian Pac J Allergy Immunol
;
1985 Dec; 3(2): 187-90
Article
in English
| IMSEAR
| ID: sea-36604
ABSTRACT
Specific cell-mediated immune response (CMIR) against rabies antigens was studied in recipients of two regimens of human diploid cell rabies vaccine (HDCV) using the antigen-stimulated lymphocyte transformation test (LTT) as a measure of CMIR. Reconstituted HDCV could be conveniently used as the in vitro stimulating antigen and the response was antigen-dependent. Conventional intramuscular immunization with full-dose HDCV resulted in positive LTT as early as 14 days after starting immunisation, and peaked on day 28. Intracutaneous immunisation with 0.1 ml of HDCV at four sites on days 0, 3 and 7 was a more efficient means of inducing specific lymphocyte response. Specific CMIR was evident as early as seven days and became maximal on day 14. In addition to the more rapid induction of specific CMIR, our intracutaneous regimen also resulted in a brisker and higher antibody response than the intramuscular regimen. The peak antibody level of the intracutaneous regimen was reached on day 14 whereas that of the intramuscular regimen was reached on day 28 and the geometric mean antibody titre on day 14 of the intracutaneous route was significantly higher than that of the intramuscular regimen. We therefore conclude that our closely spaced intracutaneous immunisation with HDCV was effective both in the induction of specific antibodies and the cell-mediated immune response.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rabies
/
Rabies virus
/
Female
/
Humans
/
Male
/
Injections, Intradermal
/
Rabies Vaccines
/
Lymphocyte Activation
/
Adolescent
/
Adult
Language:
English
Journal:
Asian Pac J Allergy Immunol
Year:
1985
Type:
Article
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