Raising rheumatoid factor cutoff helps distinguish rheumatoid arthritis.
Asian Pac J Allergy Immunol
;
2005 Jun-Sep; 23(2-3): 165-8
Article
in English
| IMSEAR
| ID: sea-36653
ABSTRACT
The presence of rheumatoid factor (RF) is one of the clinical criteria for the diagnosis of rheumatoid arthritis (RA). The cutoff point of RF assays is usually based on a reference level obtained from normal subjects in the same population as the patients. We evaluated 63 rheumatoid arthritis (RA), 25 other arthritis patients and 110 blood donors. Their rheumatoid factors (RF) ranged from < 9.9 to 2,264, < 9.9 to 262, and < 9.9 to 66 mIU/ml, respectively. The sensitivity at different cutoff points of 15, 20, and 25 mIU/ml was 92.1%, 90.5%, and 88.9%, respectively. The specificity at the same cutoff points was 81.5%, 84.4%, and 85.2%, respectively. Having minimally sacrificed the sensitivity, we recommend using a higher RF cutoff to increase specificity.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Arthritis, Rheumatoid
/
Rheumatoid Factor
/
Thailand
/
Aged, 80 and over
/
Aged
/
Female
/
Humans
/
Male
/
Case-Control Studies
/
Sensitivity and Specificity
Type of study:
Diagnostic study
/
Observational study
/
Risk factors
Limits:
Aged80
Country/Region as subject:
Asia
Language:
English
Journal:
Asian Pac J Allergy Immunol
Year:
2005
Type:
Article
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