Evidence to show MHC-linked factors other than HLA-B27 governing susceptibility to spondylo-arthropathies in Asian Indians.
Asian Pac J Allergy Immunol
;
1985 Dec; 3(2): 143-6
Article
in English
| IMSEAR
| ID: sea-36662
ABSTRACT
The HLA antigen profile of 129 North Indian patients with ankylosing spondylitis, 66 patients with Reiter's syndrome and 57 patients with 'unclassifiable' arthritis was compared with 380 normal, healthy controls. Besides B27 which appeared with a significantly increased frequency in the three patient groups, other HLA antigens, viz. A2 and B35, showed deviated frequencies. The HLA supratype A2, B27 was found to be at an elevated frequency in patients with ankylosing spondylitis and unclassifiable arthritis whereas the B35, B27 combination showed a decreased frequency in our Reiter's syndrome sample. These data suggest that besides B27, other HLA-linked factors influence susceptibility to spondylitic disorders and might act as 'modifier' genes for the type and severity of spondylo-arthropathy in a B27-positive individual.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Arthritis
/
Spondylitis, Ankylosing
/
Female
/
Humans
/
Male
/
HLA-A2 Antigen
/
HLA-B27 Antigen
/
HLA-B35 Antigen
/
Child
/
Adolescent
Country/Region as subject:
Asia
Language:
English
Journal:
Asian Pac J Allergy Immunol
Year:
1985
Type:
Article
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