Alterations of humoral immunity in patients with gastric cancer.
Asian Pac J Allergy Immunol
;
1988 Jun; 6(1): 7-10
Article
in English
| IMSEAR
| ID: sea-36696
ABSTRACT
For better understanding of the alterations of humoral immunity in gastric cancer patients, IgG, IgA, IgM, complement C3, C4, CH50, natural antibody (isohemagglutinin-IgM class), ESR, CRP, albumin and globulin were quantitated in sera taken preoperatively from 81 patients with gastric cancer and from 29 control patients with hernia. The results from patients with gastric cancer were grouped according to pTNM staging (including stage I + II, III, and IV). Serum globulin and IgG levels in all stages of cancer patients were significantly lower than that of the controls (p less than 0.05). The CRP and ESR levels in stage III and IV cancer patients were significantly higher (p less than 0.05). There was no difference between cancer and hernia patient groups in IgA, IgM, isohemagglutinin-IgM class, C3, C4, CH50, albumin, WBC and total lymphocyte counts. In conclusion, the significant changes in humoral immunity in patients with gastric cancer include (1) decrease in serum IgG and globulin levels, and (2) increased levels of acute phase reactants (ESR, CRP). These results imply that patients with gastric cancer have lower acquired humoral immunity and have acute phase reactions.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Stomach Neoplasms
/
Blood Sedimentation
/
Aged, 80 and over
/
Aged
/
Female
/
Humans
/
Male
/
C-Reactive Protein
/
Complement System Proteins
/
Immunoglobulin G
Limits:
Aged80
Language:
English
Journal:
Asian Pac J Allergy Immunol
Year:
1988
Type:
Article
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