Low dose intravenous immunoglobulin for acute immune thrombocytopenic purpura in children.
Asian Pac J Allergy Immunol
;
2001 Mar; 19(1): 11-6
Article
in English
| IMSEAR
| ID: sea-36721
ABSTRACT
Acute immune thrombocytopenic purpura (ITP) is a self-limited autoimmune disorder to platelets. The disease responds well to intravenous immunoglobulin (IVIG) treatment. We studied the efficacy of low dose (1 g/kg) IVIG to treat acute ITP in children. Of 17 children with ITP and platelet counts < 20,000/microl, 13 (76%) had rapid platelet count recovery, reaching safe level (> 50,000/microl) within 4 days after 1 g/kg IVIG. Four children needed a second dose. In 5 of 15 patients, platelet counts recovered to normal without recurrence, while in 10 patients, platelet counts declined again 2-3 weeks after the initial treatment; 6 of whom (40%) needed re-treatment. All but one patient had complete recovery of the platelet count by 6 months. Adverse effects of low dose IVIG were minimal. We recommend that for childhood ITP, 1 g/kg IVIG should be tried initially. If inadequate response is seen (platelet count < 30,000/microl) by 48 hours, a second dose is needed.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Platelet Count
/
Thailand
/
Time Factors
/
Infusion Pumps
/
Female
/
Humans
/
Male
/
Immunoglobulins
/
Child
/
Child, Preschool
Type of study:
Observational study
/
Prognostic study
Country/Region as subject:
Asia
Language:
English
Journal:
Asian Pac J Allergy Immunol
Year:
2001
Type:
Article
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