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Peripheral blood lymphocyte subsets after allogeneic bone marrow transplantation: reconstitution and correlation with the occurrence of acute graft-versus-host disease.
Asian Pac J Allergy Immunol ; 1994 Dec; 12(2): 117-23
Article in English | IMSEAR | ID: sea-36735
ABSTRACT
Peripheral blood lymphocyte subsets were enumerated at regular intervals during the first year after allogeneic bone marrow transplantation (BMT) in 21 Chinese patients. Eight of these patients had acute graft-versus-host disease (GVHD) while they were assessed at the time of engraftment. Our results show in patients receiving allogeneic BMT (1) T and NK cells were the predominant lymphocyte subsets in the early reconstitution stage while B cells were severely depleted; (2) absolute numbers of the major lymphocyte subsets normalised in 4-5 months; (3) an increased percentage of T cells that expressed the activation antigen HLA-DR and a reversed CD4CD8 ratio were observed throughout the first 12 months after BMT; (4) patients with acute GVHD had significantly higher white cell count and NK cell percentage than those not complicated by acute GVHD.
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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Transplantation, Homologous / Humans / Leukemia / HLA-DR Antigens / Acute Disease / B-Lymphocyte Subsets / T-Lymphocyte Subsets / Bone Marrow Transplantation / CD4-CD8 Ratio / Lymphocyte Count Language: English Journal: Asian Pac J Allergy Immunol Year: 1994 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Transplantation, Homologous / Humans / Leukemia / HLA-DR Antigens / Acute Disease / B-Lymphocyte Subsets / T-Lymphocyte Subsets / Bone Marrow Transplantation / CD4-CD8 Ratio / Lymphocyte Count Language: English Journal: Asian Pac J Allergy Immunol Year: 1994 Type: Article