The presence of specific IgE to salicyloyl and O-methylsalicyloyl in aspirin-sensitive patients.
Asian Pac J Allergy Immunol
;
1992 Jun; 10(1): 25-32
Article
in English
| IMSEAR
| ID: sea-36748
ABSTRACT
Certain adverse reactions to aspirin (ASA), nonsteroidal anti-inflammatory drugs (NSAIDs) and pyrazoline derivatives resemble IgE-mediated hypersensitivity. However, convincing evidence of antigen-antibody interactions or of the inhibition of the cyclooxygenase pathway of arachidonic acid metabolism leading to an increase in the generation of leukotrienes (LTs) and a decrease in the generation of prostaglandins (PGs) was not fully demonstrated. In this study, two types of specific IgE antibodies have been found in 27 serum samples from 28 ASA-sensitive patients with salicyloyl-discs and O-methylsalicyloyl-discs by Radio Allergo Sorbent Tests (RAST). The positive rates were 96.4% and 71.4%, respectively. In contrast, no positive results could be found in 10 normal donors without ASA sensitivity after ingestion of ASA 500 mg/day for 14 days. Further investigation of the chemical structure of epitopes was done by cross inhibition studies. Our results are an increasing evidence in favour of an IgE-dependent mechanism in patients suffering from ASA sensitivity. Hopefully, the determination of specific IgE antibodies will be a safe diagnostic method of ASA sensitivity in vitro.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Aged, 80 and over
/
Aged
/
Female
/
Humans
/
Male
/
Immunoglobulin E
/
Radioallergosorbent Test
/
Salicylates
/
Aspirin
/
Adult
Limits:
Aged80
Language:
English
Journal:
Asian Pac J Allergy Immunol
Year:
1992
Type:
Article
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