Evidence for free-radical mediated injury during coronary artery bypass surgery.
Indian Heart J
;
1995 Mar-Apr; 47(2): 107-11
Article
in English
| IMSEAR
| ID: sea-3679
ABSTRACT
Prolonged global ischemia followed by reperfusion during coronary artery bypass graft (CABG) surgery leads to a burst of oxygen free-radical generation and subsequent myocardial impairment. Blood samples were collected at different time periods from the right atrium of patients (n = 55) who underwent CABG surgery. Free-radical activity was measured by assays for thiobarbituric acid reactive species (TBARS), mainly malondialdehyde (MDA), at zero minute (before aortic cross-clamp), one minute and 10 minutes after declamping i.e. reperfusion. There was a significant increase (p < 0.001) in the level of MDA at one minute of reperfusion which continued to be elevated up to 10 minutes. This increase was significantly correlated with aortic cross-clamp time (r = 0.525, p < 0.05). The activity of CPK and CPK-MB was raised by two fold (p < 0.001) after release of the clamp. Plasma Troponin-T level was estimated in 10 patients during CABG surgery and a significant increase (p < 0.01) was observed at one minute as well as 10 minutes of reperfusion which correlated well (r = 0.81, p < 0.01) with the severity of ischemia. The concomitant rise in TBARS (marker of free-radical activity), CPK, CPK-MB and Troponin-T (indicators of myocardial damage) on reperfusion implies that there is free-radical mediated damage to the cardiac membrane during CABG surgery.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Troponin
/
Female
/
Humans
/
Male
/
Biomarkers
/
Myocardial Reperfusion Injury
/
Coronary Artery Bypass
/
Thiobarbituric Acid Reactive Substances
/
Reactive Oxygen Species
/
Myocardial Ischemia
Language:
English
Journal:
Indian heart j
Year:
1995
Type:
Article
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