Immunohistochemical study of c-erbB-2 expression in primary breast cancer.
Asian Pac J Allergy Immunol
;
2001 Sep; 19(3): 197-205
Article
in English
| IMSEAR
| ID: sea-36797
ABSTRACT
An immunohistochemical (IHC) study of the c-erbB-2 protein was performed in paraffin-embedded tissues from 506 primary breast carcinomas. An overexpression of c-erbB-2 was detected in 32% of the tumors and was correlated with a negative estrogen receptor status, increasing tumor size as well as axillary lymph node involvement. The five-year disease free survival was analyzed in 183 patients who have been followed for at least five years. No statistically significant association of c-erbB-2 status with survival was shown. However, longer survival in women over 50 years compared to under 50 years of age was detected among the c-erbB-2 positive patients. In the multivariate Cox's regression analysis, lymph node and vascular invasions were independent prognostic indicators among these patients. But c-erbB-2 status and other factors did not predict the relapse of breast cancer. However, these data may not negate the benefit of c-erbB-2 detected by IHC for identification of patients who have a poor prognosis and require more aggressive adjuvant therapy. Further studies in a larger group of patients with longer follow-up time may provide more valid information.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Prognosis
/
Aged, 80 and over
/
Breast Neoplasms
/
Aged
/
Female
/
Humans
/
Immunohistochemistry
/
Receptors, Progesterone
/
Receptors, Estrogen
/
Gene Expression
Type of study:
Prognostic study
Limits:
Aged80
Language:
English
Journal:
Asian Pac J Allergy Immunol
Year:
2001
Type:
Article
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