Predictors of renal involvement in patients with systemic lupus erythematosus.
Asian Pac J Allergy Immunol
;
2007 Mar; 25(1): 17-25
Article
in English
| IMSEAR
| ID: sea-36881
ABSTRACT
From a cohort of 109 patients (105 females and 4 males) treated for systemic lupus erythematosus (SLE), 20 patients (18.3%) developed new episodes of lupus nephritis and 89 patients (81.7%) remained free of renal involvement during the follow-up period. The mean duration of follow up was 39.1 +/- 54.4 months. Clinical characteristics associated with developing lupus nephritis were a high systolic blood pressure (> or = 130 mmHg), photosensitivity, cutaneous vasculitis and gastrointestinal (GI) symptoms. Laboratory abnormalities associated with the development of lupus nephritis were hemoglobin < 10 mg/dl, hematocrit < 30%, blood urea nitrogen > 12 mg/dl, serum creatinine > 1.3 mg/dl, ESR > 60, the third component of complement (C3) level < 0.45 and positive antidsDNA antibody. After a multivariable analysis, only high systolic blood pressure, cutaneous vasculitis, hemoglobin < 10 mg/dl and serum creatinine > 1.3 mg/dl remained as statistically significant risk factors for developing lupus nephritis.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Lupus Nephritis
/
Female
/
Humans
/
Male
/
Antibodies, Antinuclear
/
Risk Factors
/
Cohort Studies
/
Adult
/
Hypertension
/
Kidney
Type of study:
Etiology study
/
Incidence study
/
Observational study
/
Prognostic study
/
Risk factors
Language:
English
Journal:
Asian Pac J Allergy Immunol
Year:
2007
Type:
Article
Similar
MEDLINE
...
LILACS
LIS