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Predictors of renal involvement in patients with systemic lupus erythematosus.
Asian Pac J Allergy Immunol ; 2007 Mar; 25(1): 17-25
Article in English | IMSEAR | ID: sea-36881
ABSTRACT
From a cohort of 109 patients (105 females and 4 males) treated for systemic lupus erythematosus (SLE), 20 patients (18.3%) developed new episodes of lupus nephritis and 89 patients (81.7%) remained free of renal involvement during the follow-up period. The mean duration of follow up was 39.1 +/- 54.4 months. Clinical characteristics associated with developing lupus nephritis were a high systolic blood pressure (> or = 130 mmHg), photosensitivity, cutaneous vasculitis and gastrointestinal (GI) symptoms. Laboratory abnormalities associated with the development of lupus nephritis were hemoglobin < 10 mg/dl, hematocrit < 30%, blood urea nitrogen > 12 mg/dl, serum creatinine > 1.3 mg/dl, ESR > 60, the third component of complement (C3) level < 0.45 and positive antidsDNA antibody. After a multivariable analysis, only high systolic blood pressure, cutaneous vasculitis, hemoglobin < 10 mg/dl and serum creatinine > 1.3 mg/dl remained as statistically significant risk factors for developing lupus nephritis.
Subject(s)
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Lupus Nephritis / Female / Humans / Male / Antibodies, Antinuclear / Risk Factors / Cohort Studies / Adult / Hypertension / Kidney Type of study: Etiology study / Incidence study / Observational study / Prognostic study / Risk factors Language: English Journal: Asian Pac J Allergy Immunol Year: 2007 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Lupus Nephritis / Female / Humans / Male / Antibodies, Antinuclear / Risk Factors / Cohort Studies / Adult / Hypertension / Kidney Type of study: Etiology study / Incidence study / Observational study / Prognostic study / Risk factors Language: English Journal: Asian Pac J Allergy Immunol Year: 2007 Type: Article