The effects of exogenous interleukin-12 on the induction of immune response to Porphyromonas gingivalis in vivo in mice.
Asian Pac J Allergy Immunol
;
2001 Mar; 19(1): 59-62
Article
in English
| IMSEAR
| ID: sea-36915
ABSTRACT
The effects of treatment with exogenous interleukin-12 (IL-12) on the induction of immune response to Porphyromonas gingivalis, a black pigmented periodontopathic oral bacterium in mice, were determined in the present study. An increased footpad swelling representing a delayed type hypersensitivity (DTH) response to P. gingivalis in IL-12-treated mice could be observed, although increasing doses of IL-12 did not produce cumulative effects on this cellular Immune response. Multiple injections with IL-12 also resulted in elevated serum IFN-gamma levels. Treatment with this cytokine the day before, on and after immunization with heat-killed P. gingivalis augmented the levels of serum antigen-specific IgG2a and IgG3 antibodies, but had obviously little or no effects on those of serum antigen-specific IgG1 and IgG2b antibodies. The results of this study suggest that treatment with exogenous IL-12 In P. gingivalis-immunized mice may enhance DTH response and Th1 cell-associated antibody production.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Virus Activation
/
Female
/
Histocompatibility Antigens Class II
/
Adjuvants, Immunologic
/
Interferon-gamma
/
Bacteroidaceae Infections
/
Porphyromonas gingivalis
/
Interleukin-12
/
Models, Animal
/
Dose-Response Relationship, Immunologic
Type of study:
Prognostic study
Language:
English
Journal:
Asian Pac J Allergy Immunol
Year:
2001
Type:
Article
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