Ketotifen inhibits allergen-specific T lymphocytes' responses by suppressing antigen presentation with concomitant decrease of HLA-DQ antigen on macrophages.
Asian Pac J Allergy Immunol
;
1996 Dec; 14(2): 69-79
Article
in English
| IMSEAR
| ID: sea-36949
ABSTRACT
Allergen activates T lymphocytes responsive to interleukin 2 (IL-2) in allergic patients but not in normal individuals. This response was suppressed by anti-allergic agent, Ketotifen (4-(1-methyl-4-piperidylidene)-4H-benzo [4, 5] cyclohepta [1, 2-b] thiophen-10 (9H)-one hydrogen (fumarate). Prolonged culture of antigen-presenting adherent cells impaired the ability to present Dermatophagoides farinae (Df) antigen to T cells, whereas stimulation of adherent cells with recombinant interferon-gamma (IFN-gamma) restored the antigen-presenting capability. The maintained antigen presenting ability of adherent cells treated with IFN-gamma was also suppressed by Ketotifen. Fluorescence activated cell sorter (FACS) analysis disclosed that Ketotifen selectively reduced the expression of HLA-DQ antigen, crucial restriction elements in Df antigen-related responses, on macrophages but not on B cells, even in the presence of IFN-gamma. Collectively, Ketotifen prevented macrophages from inducing allergen-activated T lymphocytes' responsiveness to IL-2 at least in part by decreasing the expression of HLA-DQ antigen.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Asthma
/
Humans
/
T-Lymphocytes
/
HLA-DQ Antigens
/
Cell Adhesion
/
Cells, Cultured
/
Child
/
Child, Preschool
/
Adolescent
/
Interleukin-4
Language:
English
Journal:
Asian Pac J Allergy Immunol
Year:
1996
Type:
Article
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