HLA-A, -B and -DR allele and haplotype frequencies in Malays.
Asian Pac J Allergy Immunol
;
2007 Mar; 25(1): 47-51
Article
in English
| IMSEAR
| ID: sea-37097
ABSTRACT
One thousand four hundreds and forty-five Malays registered with the Malaysian Marrow Donor Registry were typed for HLA-A, HLA-B and HLA-DR. Fifteen HLA-A, twenty nine HLA-B and fourteen HLA-DR alleles were detected. The most common HLA-A alleles and their frequencies were HLA-A24 (0.35), HLA-A11 (0.21) and HLA-A2 (0.15). The most common HLA-B alleles were HLA-B15 (0.26), HLA-B35 (0.11) and HLA-B18 (0.10) while the most common HLA-DR alleles were HLA-DR15 (0.28), HLA-DR12 (0.27) and HLA-DR7 (0.10). A24-B15-DR12 (0.047), A24-B15-DR15 (0.03) and the A24-B35-DR12 (0.03) were the most frequent haplotypes. This data may be useful in determining the probability of finding a matched donor and for estimating the incidence of HLA associated diseases.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Haplotypes
/
Female
/
Humans
/
Male
/
Histocompatibility Testing
/
HLA-A Antigens
/
HLA-B Antigens
/
HLA-DR Antigens
/
Cohort Studies
/
Alleles
Type of study:
Etiology study
/
Incidence study
/
Observational study
/
Risk factors
Country/Region as subject:
Asia
Language:
English
Journal:
Asian Pac J Allergy Immunol
Year:
2007
Type:
Article
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