Evaluation of threshold criteria for the nasal histamine challenge test in perennial allergic rhinitis.
Asian Pac J Allergy Immunol
;
1997 Jun; 15(2): 65-9
Article
in English
| IMSEAR
| ID: sea-37140
ABSTRACT
Nasal reactivity to histamine was determined in patients with perennial allergic rhinitis and in control subjects. A histamine titration method delivered by a metered dose pump was used. Stuffiness, itching, and the number of sneezes were recorded, nasal secretions measured, and nasal airway resistance was recorded by active anterior rhinomanometry. Increased nasal reactivity to histamine was observed among rhinitic patients and inversely correlated with the severity of nasal symptoms. A 3-fold increase of post-saline nasal airway resistance (NAR) best differentiated the nasal responses to histamine in rhinitic patients from those in control subjects. A histamine dose of < or = 2.5 microg provoked a 3-fold increase in NAR, strongly suggesting moderate or severe symptomatic rhinitis in most cases. Nasal provocation techniques might be a useful tool for objectively assessing disease severity and response to treatment in perennial allergic rhinitis.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pruritus
/
Sneezing
/
Severity of Illness Index
/
Female
/
Humans
/
Male
/
Histamine
/
Nasal Obstruction
/
Child
/
Rhinitis, Allergic, Perennial
Type of study:
Diagnostic study
Language:
English
Journal:
Asian Pac J Allergy Immunol
Year:
1997
Type:
Article
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