Cell-mediated immunosuppression in mice by street rabies virus not restored by calcium ionophore or PMA.
Asian Pac J Allergy Immunol
;
1997 Sep; 15(3): 127-32
Article
in English
| IMSEAR
| ID: sea-37184
ABSTRACT
It is known that rabies virus can suppress the host immune system. In this study we demonstrate a depression of cell-mediated immunity in mice, peripherally infected with Thai street rabies virus. The cell-mediated cytolysis of spleen cells from mice increased transiently on day 5 after infection and declined rapidly thereafter until death. The proliferation of spleen cells stimulated with a T-cell mitogen such as phytohemagglutinin or concanavalin A, was significantly suppressed during the course of infection. There was also a marked suppression of IL-2 secretion in parallel with a decrease of the T-cell proliferative response to mitogen. The suppression of T-cell proliferation was not restored by treatment with a calcium ionophore (A 23187) or phorbol 12-myristate-13 acetate (PMA).
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rabies
/
Rabies virus
/
Protein Kinase C
/
Tetradecanoylphorbol Acetate
/
Lymphocyte Activation
/
T-Lymphocytes
/
Cations, Divalent
/
Calcium
/
Calcimycin
/
Immunosuppression Therapy
Language:
English
Journal:
Asian Pac J Allergy Immunol
Year:
1997
Type:
Article
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