Regulation of immunoglobulin secretion by T lymphocytes in human malaria.
Asian Pac J Allergy Immunol
;
1986 Jun; 4(1): 13-7
Article
in English
| IMSEAR
| ID: sea-37210
ABSTRACT
In vitro studies were carried out on the nature of immunoglobulin synthesis and secretion by peripheral blood mononuclear leukocytes (PBMLs) and on the function of T and B cells from malaria patients. The mean values of secreted IgG and IgM concentrations of 22 malaria patient PMBLs were significantly higher than those of 20 normal PBMLs. When the suppressor T cell activity and the function of B cells in response to suppressor T cells were assayed by the cell co-culture technique, it was found that there was a decrease in suppressor T cell activity and the B cell function in response to normal suppressor T cells in malaria patients. The defects of these T and B cell functions may play some role in the immunological abnormalities seen in some malaria patients.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pokeweed Mitogens
/
Humans
/
Immunoglobulin G
/
Immunoglobulin M
/
Immunoglobulins
/
T-Lymphocytes
/
T-Lymphocytes, Regulatory
/
Malaria
Language:
English
Journal:
Asian Pac J Allergy Immunol
Year:
1986
Type:
Article
Similar
MEDLINE
...
LILACS
LIS