Basement membrane antibodies in Alport's syndrome.
Asian Pac J Allergy Immunol
;
1991 Jun; 9(1): 31-7
Article
in English
| IMSEAR
| ID: sea-37254
ABSTRACT
By the indirect immunofluorescent technique, sera from patients with Alport's syndrome showed a reaction with the basement membrane of the capillary wall of glomeruli and peritubular vessels and nearby interstitial tissue of normal monkey and mouse kidney as a substrate. It also revealed bright staining to the matrix surrounding the clusters of EHS tumor cells and stromal tissues. These reactions were caused by autoantibodies present in these sera. These findings were supported by the detection of antilaminin, nidogen and anti collagen type VI in the sera by ELISA method. These evidences suggest that the Alport's patients developed stage of autoimmunity. The exact causes were not so clear, but seemed to be due to multiple factors.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Autoantibodies
/
Basement Membrane
/
Fibrosis
/
Humans
/
Microscopy, Electron
/
Fluorescent Antibody Technique
/
Kidney Glomerulus
/
Nephritis, Hereditary
Language:
English
Journal:
Asian Pac J Allergy Immunol
Year:
1991
Type:
Article
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