Comparative genomic hybridization (CGH) analysis of chromosomal aberrations in Iranian patients with invasive ductal carcinoma breast cancer.
Article
in English
| IMSEAR
| ID: sea-37341
ABSTRACT
INTRODUCTION:
Breast cancer is one of the most common cancers in women; however, due to the complexity of chromosomal changes, limited data are available regarding chromosomal constitution. MATERIALS ANDMETHODS:
In this study, Comparative Genomic Hybridization (CGH) was used on 16 Iranian patients diagnosed with invasive ductal breast carcinomas.RESULTS:
12 samples had abnormal CGH results (75%), including 21 types of chromosomal imbalance. The most prevalent were chromosomal gain of +1q, +17q, +8q and chromosomal loss of -13q. All three cases with DNA loss at chromosome 13q (-13q) had lymph node metastasis.CONCLUSIONS:
CGH is able to detect chromosomal abnormalities which are difficult to identify by conventional cytogenetic techniques. More studies on a larger sample size may help to confirm or rule out any possible correlation between 13q monosomy and lymph node metastasis, which could result in establishing new strategies for prevention and early detection of invasive breast tumors.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Prognosis
/
Chromosomes, Human, Pair 1
/
Chromosomes, Human, Pair 8
/
Chromosomes, Human, Pair 13
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Chromosomes, Human, Pair 17
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Image Processing, Computer-Assisted
/
Breast Neoplasms
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Aged
/
Female
/
Humans
Type of study:
Prognostic study
/
Screening study
Country/Region as subject:
Asia
Language:
English
Year:
2008
Type:
Article
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