Efficacy of cisplatin in early stage cervical cancer with a long waiting period for surgery.
Article
in English
| IMSEAR
| ID: sea-37521
ABSTRACT
This study was undertaken as a prospective trial to evaluate the efficacy and safety of pre-operative cisplatin for controlling the tumor volume of stage IB-IIA cervical cancer patients whose schedule for radical surgery was longer than 3 weeks. Between June 2004 and July 2005, 42 patients were recruited to enter the study. Seventy-five mg/m(2) of cisplatin was administered for 1-2 courses. Cervical tumor volume was measured 1 day before chemotherapy and 1 day before the operation by using 3-dimensional ultrasound. Reduction of cervical tumor volume was noted in 76.2%of cases. The clinical stage, gross appearance of the tumor, histology and number of chemotherapy courses did not significantly affect chemo-responsiveness. The incidence of lymph node metastases was 16.3%. One patient experienced severe vomiting which could be controlled by ondansetron antiemetic. No severe hematologic or other non-hematologic toxicities were identified. In conclusion cisplatin is effective and safe for administration in a pre-operative setting for early stage cervical cancer patients whose surgical schedule is delayed more than 3 weeks.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Time Factors
/
Preoperative Care
/
Female
/
Humans
/
Carcinoma, Squamous Cell
/
Adenocarcinoma
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Uterine Cervical Neoplasms
/
Prospective Studies
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Cisplatin
/
Adult
Type of study:
Observational study
/
Prognostic study
Language:
English
Year:
2007
Type:
Article
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