Obesity, breast cancer and the role of adipocytokines.
Article
in English
| IMSEAR
| ID: sea-37762
ABSTRACT
Obesity is a worldwide problem which impacts the risk and prognosis of some of the more common forms of cancer, including breast cancer in post-menopausal women. As the basis for understanding the potential mechanisms of obesity and cancer relationship has advanced, a number of new hypotheses have emerged. The adipocytokines are a complex group of biologically active polypeptides. Leptin is a growth hormone, secreted by adipose tissue, whose levels are normally elevated in obese individuals and may have a promoting effect on carcinogenesis and metastasis of breast cancer, possibly in an autocrine manner. Leptin interferes with the insulin signaling pathway and in type 2 diabetes plasma leptin levels are found to be correlated with the degree of insulin resistance, a relationship independent of body mass. This relationship might provide a mechanistic explanation for promotion potential.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Breast Neoplasms
/
Female
/
Humans
/
Cytokines
/
Adipocytes
/
Peptide Hormones
/
Obesity
Language:
English
Year:
2005
Type:
Article
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