Immunoglobulin heavy and light chain isotypes in multiple myeloma patients.
Article
in English
| IMSEAR
| ID: sea-37841
ABSTRACT
The frequency of expression of immunoglobulin (Ig) light and heavy chain isotypes was analyzed in myeloma proteins (M-proteins) from sera of 40 Indian patients with clinically established multiple myeloma. Patients samples were screened by a combination of electrophoresis, immunoelectrophoresis (IEP) and ELISA techniques in this study. We found that majority of the myeloma proteins (58%) were of the IgG isotype followed by IgA (24%) and biclonal gammopathy associated with IgG and IgA (5%). Both kappa and lambda light chains were associated with the heavy chain isotypes. We recommend the triangular combination for detection of M-proteins and biclonal gammopathy of cancerous plasma cells as biomarkers for diagnosis of myeloma.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Prognosis
/
Humans
/
Immunoglobulins
/
Enzyme-Linked Immunosorbent Assay
/
Immunoelectrophoresis
/
Immunoglobulin Heavy Chains
/
Immunoglobulin Light Chains
/
Multiple Myeloma
Type of study:
Prognostic study
Language:
English
Year:
2007
Type:
Article
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