Do TNFA -308 G/A and IL6 -174 G/C gene polymorphisms modulate risk of gallbladder cancer in the north Indian population?
Article
in English
| IMSEAR
| ID: sea-38047
ABSTRACT
OBJECTIVES:
Gallbladder carcinoma (GBC) is highly aggressive neoplasm which arises in the background of gall stones and inflammation. GBC affects women 2-3 times more frequently than men. Pro-inflammatory TNFA and IL6 gene polymorphism has been associated with various inflammatory diseases. The aim of this study was to investigate whether TNFA -308 (G/A) and IL6 -174 G/C polymorphisms within flanking region of the genes are associated with GBC susceptibility.METHODS:
The promoter polymorphisms were genotyped using PCR-RFLP in 200 healthy subjects and 124 GBC patients.RESULTS:
Frequency distribution of TNFA -308 (G/A) and IL6 -174 G/C were not significantly different in GBC patients in comparison to healthy controls. However, frequency of TNFA -308 (G/A) polymorphism in female GBC patients without gallstone were significantly different (p-value= 0.006) when compared to healthy female subjects (OR=3.054; 95% CI=1.39-6.72).CONCLUSION:
These results suggest that TNFA -308 (G/A) polymorphism may influence the susceptibility of female gender gallbladder cancer in absence of gallstones while IL6 -174 G/C polymorphism does not seem to be playing significant role in the susceptibility to gallbladder cancer.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Polymorphism, Restriction Fragment Length
/
Female
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Humans
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Male
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Case-Control Studies
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Polymerase Chain Reaction
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Risk Factors
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Interleukin-6
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Tumor Necrosis Factor-alpha
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Genetic Predisposition to Disease
Type of study:
Etiology study
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Observational study
/
Risk factors
Country/Region as subject:
Asia
Language:
English
Year:
2007
Type:
Article
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