Decreased suppressor T-lymphocytes in women who received progestogen injections.
Article
in English
| IMSEAR
| ID: sea-38461
ABSTRACT
Decreased levels of suppressor T-cells (CD8+) were found in 17 normal women who received progestogen (Depoprovera) injection, 150 mg intramuscularly every three months for contraceptive purposes, for more than 30 months. The helper suppressor T-cells (CD4+ CD8+ ratio) was significantly elevated in this group compared to 30 normal female controls. No significant change of T-lymphocyte was found in 53 normal women who received the injection for less than 30 months or who received combined oral contraceptive pills. In conclusion, long term progestogen injection induced a lowering of suppressor T-cell levels, which is the same immunological change found in several autoimmune diseases.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Progesterone
/
Female
/
Humans
/
CD4-CD8 Ratio
/
T-Lymphocytes, Regulatory
/
Injections, Intramuscular
/
Leukocyte Count
Language:
English
Year:
1992
Type:
Article
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