Effect of dialyzer membranes on beta-2 microglobulin production in Thai hemodialysis patients.
Article
in English
| IMSEAR
| ID: sea-38565
ABSTRACT
Responses to different types of dialyzer membranes in an Asian population may differ from those of a Caucasian population. Comparative studies on the effects of different dialyzer membranes on beta-2 microglobulin production are also limited. Therefore, we conducted this study to determine the effects of different dialyzer membranes on in vitro mononuclear cell production of beta-2 microglobulin in 9 Thai hemodialysis patients. Each patient was dialysed with 4 different types of dialyzer, including cuprophane (CUP), cellulose diacetate (CD), polysulphone (PS), and polyacrylonitrile membrane (PAN), each for a 1-month period in a randomized sequence. Mononuclear cell culture was done by taking an immediate post-dialysis blood sample at the end of the 1-month period. Beta-2 microglobulin production from cell culture was determined 24 hours later. Mononuclear cell culture and determination of beta-2 microglobulin production from the culture were also done in 10 normal controls and 10 predialysis ESRD patients. The beta-2 microglobulin productions (microgram/L) were shown as follows; Control CUP CD PS PAN [table see text] (*p < 0.05 compared to cuprophane membrane). Conclusion:
polysulphone and polyacrylonitrile membrane induced significantly less beta-2 microglobulin production compared to cuprophane and slightly less compared to cellulose diacetate membrane.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Polymers
/
Sulfones
/
Thailand
/
Biocompatible Materials
/
Acrylic Resins
/
Female
/
Humans
/
Male
/
Cellulose
/
Analysis of Variance
Type of study:
Controlled clinical trial
Country/Region as subject:
Asia
Language:
English
Year:
1997
Type:
Article
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