The effect of spironolactone on the rat uterus.

Coksevim, B; Tayyar, M

Coksevim, B; Tayyar, M.

Article in English | IMSEAR | ID: sea-39246

ABSTRACT

ABSTRACT

Our experimental study showed that in a dose related manner SP has successful inhibitory effect on the rat uterine horn, and also on the smooth muscle organs; ileum and trachea. We guess that SP can be used in well regulated dosed with least side effects to arrest preterm labor on human being in the future. Up to date there is no manuscript about contraction inhibitory effect of SP on the uterus. We hope this study will be of scientific help.

Subject(s)

Animals; Diethylstilbestrol/pharmacology; Dose-Response Relationship, Drug; Female; Ileum/drug effects; Isoxsuprine/administration & dosage; Muscle Contraction/drug effects; Rats; Rats, Inbred Strains; Ritodrine/administration & dosage; Spironolactone/administration & dosage; Trachea/drug effects; Uterine Contraction/drug effects

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Rats / Rats, Inbred Strains / Ritodrine / Spironolactone / Trachea / Uterine Contraction / Female / Diethylstilbestrol / Dose-Response Relationship, Drug / Ileum Language: English Year: 1994 Type: Article

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