Isobolographically additive anticonvulsant activity between Centella asiatica's ethyl acetate fraction and some antiepileptic drugs.
Article
in English
| IMSEAR
| ID: sea-39320
ABSTRACT
OBJECTIVE:
To investigate interaction between orally given Centella asiatica's ethyl acetate fraction (EACA) and intraperitoneally administered antiepileptic drugs (AEDs), namely, phenytoin, valproate and gabapentin. MATERIAL ANDMETHOD:
Isobolographic analysis was used to evaluate the interaction between EACA and AEDs in terms of protection of mice in the pentylenetetrazole test. Rotarod test was used to evaluate neurotoxicity.RESULTS:
When given alone, the median effective dose of phenytoin, valproate and gabapentin were found to be 13, 104, and 310 mg/kg BW, respectively, whereas the corresponding values in the presence of EACA were 5, 29 and 79 mg/kg BW. Together with isobolographic analysis, the results obtained indicated an additive effect among all combinations tested. In relation to neurotoxicity, combination of gabapentin and EACA demonstrated a broader margin between the effective dose and the neurotoxic dose while the other two combinations did not.CONCLUSION:
The present finding suggested a potential of Centella asiatica to be developed as an adjunctive medication for epileptic patients.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Seizures
/
Male
/
Plant Extracts
/
Centella
/
Herb-Drug Interactions
/
Disease Models, Animal
/
Drug Therapy, Combination
/
Animals
/
Phytotherapy
/
Mice
Type of study:
Prognostic study
Language:
English
Year:
2005
Type:
Article
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