Serum vitamin D, parathyroid hormone and biochemical markers of bone turnover in normal Thai subjects.

ABSTRACT

The sera from 158 healthy Thai volunteers (77 males and 81 females), aged 20-80 years, were studied. The vitamin D status, parathyroid gland activity and the magnitude of bone turnover were assessed by measurement of serum 25-hydroxycholecalciferol (25-OH-D), intact parathyroid hormone (N-tact-PTH), osteocalcin and alkaline phosphatase. The mean serum 25-OH-D, N-tact-PTH, osteocalcin and alkaline phosphatase concentrations in men were 67.4 +/- 31.6 (S.D.) [Range (R) 20.6-147.1 ng/ml], 23.3 +/- 10.3 (R 5.6-56.6 pg/ml) 3.4 +/- 1.5 (R 1.2-10.5 ng/ml), and 19.9 +/- 6.6 (R 7.5-35.7 IU/L), respectively, and the mean levels in women were 42.4 +/- 23.9 (R 13.8-127.8 ng/ml), 26.1 +/- 11.3 (R 10.5-68.7 pg/ml), 3.7 +/- 2.1 (R 0.5-11.5 ng/ml), and 19.5 +/- 6.0 (R 9.1-41.5 IU/L), respectively. There is no evidence of vitamin D deficiency in ambulatory elderly Thais. Serum N-tact PTH increased with advancing age in both men and women whereas increasing serum osteocalcin and alkaline phosphatase with age were observed only in women. In addition, serum alkaline phosphatase correlated to serum osteocalcin only in women suggesting an increase in bone turnover after menopause. These basic data would be useful for the study of metabolic bone diseases in Thai population.