Mortality analysis of HIV-1 infected patients for prioritizing antiretroviral drug therapy.
Article
in English
| IMSEAR
| ID: sea-39499
ABSTRACT
Mortality data of patients, classified according to their clinical status and CD4+ cell count status, would be very useful to guide clinicians to prioritizing patients who need antiretroviral drug therapy. In the current study, the authors re-analyzed data derived from a previously published retrospective study of HIV-1-infected individuals at Lampang Hospital in northern Thailand. According to the Cox proportional hazard model, compared to asymptomatic patients with a high CD4+ cell count (> 200 cell/microl), the mortality rate of asymptomatic patients with a medium CD4+ cell count (100-199 cell/microl) did not significantly differ. However, the mortality rate of patients with a CD4+ cell count below 100 cell/microl was at least 16 times higher, regardless of the presence of clinical symptoms. Based on these results, the authors produced a Lampang Hospital guideline of antiretroviral drug use; priority of antiretroviral therapy should, therefore, be given to patients with CD4+ cell count < 100 cell/microl.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Humans
/
HIV Infections
/
Proportional Hazards Models
/
Retrospective Studies
/
Risk Factors
/
HIV-1
/
CD4 Lymphocyte Count
/
Anti-HIV Agents
Type of study:
Etiology study
/
Practice guideline
/
Observational study
/
Prognostic study
/
Risk factors
Language:
English
Year:
2004
Type:
Article
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