Extranodal malignant lymphoma of the upper aerodigestive tract: prevalence of Epstien-Barr virus (EBV) infection in King Chulalongkorn Memorial Hospital.
Article
in English
| IMSEAR
| ID: sea-39664
ABSTRACT
BACKGROUND:
High frequency of Epstein-Barr virus (EBV) in the normal mucosa of the upper aerodigestive tract suggests that it may serve as a reservoir for the virus. Malignant lymphomas arising in this site may be associated with EBV.OBJECTIVES:
To determine the prevalence of EBV infection in extranodal malignant lymphomas of the upper aerodigestive tract.SETTING:
King Chulalongkorn Memorial Hospital, Thailand.DESIGN:
Descriptive study. PATIENTS 42 Thai patients who presented between 1998 and 2003. MATERIAL ANDMETHOD:
The expression of EBV mRNAs (EBERs) of malignant lymphoma was studied by means of in situ hybridization in formalin-fixed, paraffin-embedded specimens.RESULTS:
The recruited subjects were 26 males and 16 females, and their age ranged from 3 to 85 years with the mean of 51.43 years, in 4 of them human immune deficiency virus (HIV) infection was documented. Ten of 42 cases (23.81%) expressed EBER transcripts and were extranodal NK/T-cell lymphomas, nasal type (7 cases), plasmablastic lymphomas (2 cases) and diffuse large B-cell lymphoma (1 case). Three of 4 cases (75%) of known HIV-seropositive cases were EBV-positive (2 plasmablastic lymphomas and 1 diffuse large B-cell lymphoma).CONCLUSION:
In the upper aerodigestive tract, EBV was present in some but not all malignant lymphoma. It was associated with extranodal NK/T-cell lymphoma, nasal type and B-cell lymphoma arising in HIV-infected patients, but it was not found in B-cell lymphoma arising in immunocompetent patients.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Respiratory System
/
Thailand
/
Aged, 80 and over
/
Aged
/
Female
/
Humans
/
Male
/
Disease Reservoirs
/
Child
/
Child, Preschool
Type of study:
Etiology study
/
Prevalence study
/
Risk factors
Limits:
Aged80
Country/Region as subject:
Asia
Language:
English
Year:
2005
Type:
Article
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