Isoniazid-rifampicin-induced submassive hepatic necrosis.
Article
in English
| IMSEAR
| ID: sea-39753
ABSTRACT
A 58-year-old woman with tuberculosis received antituberculous drugs which included isoniazid, rifampicin, and ethambutol. Nausea and anorexia were initial symptoms while jaundice and abdominal pain were late manifestations. She became comatose and died 7 weeks after therapy. Autopsy revealed submassive necrosis of the liver and active advanced pulmonary tuberculosis. It is, thus, necessary for the physician to be alert for this serious complication in prescribing a combination of these antituberculous drugs.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rifampin
/
Female
/
Humans
/
Hepatic Encephalopathy
/
Chemical and Drug Induced Liver Injury
/
Isoniazid
/
Liver
/
Middle Aged
/
Necrosis
Language:
English
Year:
1989
Type:
Article
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