Hematopoietic stem cell transplantation for patients with advanced-stage follicular lymphoma.
Article
in English
| IMSEAR
| ID: sea-39930
ABSTRACT
Patients with advanced-stage follicular lymphoma (FL) are considered to be incurable and eventually relapse after conventional chemotherapy. High-dose therapy (HDT) followed by autologous hematopoietic stem cell transplantation (AHSCT) can unequivocally prolong the disease-free survival (DFS) but not overall survival (OS) in the first complete remission and in a salvage setting. Recently, the incorporation of rituximab and radioimmunoconjugates in HDT with AHSCT seems to be promising and widely accepted. Although allogeneic hematopoietic stem cell transplantation (alloHSCT) consistently demonstrates longer DFS compared with historical controls of HDT followed by AHSCT, this approach cannot be considered as a standard of care due to its unacceptably high treatment-related mortality (TRM) and the lack of improving OS. With highly encouraging results and less TRM, the role of nonmyeloablative hematopoietic stem cell transplantation (NMHSCT), especially after AHSCT needs to be validated in randomized controlled trials with a long-term follow-up.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Survival
/
Time Factors
/
Transplantation, Homologous
/
Humans
/
Lymphoma, Follicular
/
Salvage Therapy
/
Hematopoietic Stem Cell Transplantation
Type of study:
Controlled clinical trial
Language:
English
Year:
2008
Type:
Article
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