Survey of human papillomavirus infection in cervical intraepithelial neoplasia in Thai women.
Article
in English
| IMSEAR
| ID: sea-40235
ABSTRACT
HPV infection is known to be associated with cervical cancer development. Precancerous lesions named cervical intraepithelial neoplasia (CIN) are divided into 3 grades, i.e., CIN-1, CIN-2, and CIN-3. Here, HPV infection determined by PCR and dot hybridization was observed in these 3 different grades of formalin-fixed paraffin embedded tissues. The HPV infection was demonstrated in 33.3 per cent of CIN-1, 36.8 per cent of CIN-2 and 75 per cent of CIN-3. Using type specific probes for HPV-6, 11, 16, 18 and 33, HPV-16 was the most prevalent type (44.44%) followed by HPV-18 (16.05%) in CIN-3. Only one HPV-18 was identified in CIN-1 while CIN-2 contained one HPV-6 and one HPV-18. Mixed infection was found in CIN-3 (12.35%). All of them had HPV-16. The cervicitis cases with normal histopathology were included as control. Only 2.7 per cent of HPV infection was shown. The relative risk of HPV infection was high in CIN-3 (OR = 107.25, 95% CI = 50.29-228.73). Our data confirm the association between high-risk HPV types and development of CIN.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Papillomaviridae
/
Precancerous Conditions
/
Reference Values
/
Thailand
/
Tumor Virus Infections
/
Biopsy, Needle
/
Aged
/
Female
/
Humans
/
Immunohistochemistry
Type of study:
Diagnostic study
/
Etiology study
/
Observational study
/
Risk factors
Country/Region as subject:
Asia
Language:
English
Year:
2002
Type:
Article
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