The relation between parameters from homeostasis model assessment and glycemic control in type 2 diabetes.
Article
in English
| IMSEAR
| ID: sea-40355
ABSTRACT
OBJECTIVE:
To determine the association of insulin sensitivity and pancreatic beta-cell function parameters assessed by the homeostasis model assessment (HOMA) and glycemic control, and their potential utilization in the clinical care of patients with type 2 diabetes mellitus. MATERIAL ANDMETHOD:
The HOMA indices were assessed in 204 (62 males, 142 females) type 2 diabetic outpatients aged 60.7 +/- 10.9 years. All patients were non-insulin treated for their diabetes. The correlation between variables including logarithmically transformed HOMA-%S and HOMA-%B, body mass index (BMI) and duration of diabetes to glycemic control were assessed The value of the disposition index (HOMA-%SxHOMA-%B) that best discriminated patients with good glycemic control (HbA1C < 7%) from those without (HbA1C > or = 7%) was determined.RESULTS:
Both log (HOMA-%S) and log (HOMA-%B) were inversely related to HbA1C with comparable degrees of association (beta = -0.62, p < 0.001 and beta = -0.61, p < 0.001, respectively). The log-transformed disposition index of at least 3.57 had a sensitivity of 74.2% and a specificity of 67.6% in classifying patients as having HbA1C < 7%. The result suggested that in order to achieve acceptable glycemic control, oral hypoglycemic agents should be adjusted to maximize the likelihood of the log-transformed disposition index reaching 3.57.CONCLUSIONS:
Glycemic control in diabetic patients partially depends on both insulin sensitivity and pancreatic beta-cell function. Assessing both parameters with the HOMA model is likely to result in a more rational approach for achieving better glycemic control in type 2 diabetic patients.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Blood Glucose
/
Female
/
Humans
/
Male
/
Glycated Hemoglobin
/
Body Mass Index
/
Pilot Projects
/
Health Status Indicators
/
Sickness Impact Profile
/
Diabetes Mellitus, Type 2
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Language:
English
Year:
2007
Type:
Article
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