Clinical outcomes and prognostic factors of node-negative cervical cancer patients with deep stromal invasion or lymphovascular space involvement following radical hysterectomy.
Article
in English
| IMSEAR
| ID: sea-40648
ABSTRACT
OBJECTIVE:
To evaluate the clinical outcomes and prognostic factors of node-negative cervical cancer patients who had deep stromal invasion (DSI) and/or lymphovascular space invasion (LVSI) following radical hysterectomy and pelvic lymphadenectomy (RHPL). MATERIAL ANDMETHOD:
The medical records of 150 node-negative stage IA2-IIA cervical cancer patients who had DSI and/or LVSI after RHPL from 1999 to 2004 were reviewed.RESULTS:
Eighty-eight (58.4%) patients were treated with RHPL alone. Twenty-eight (18.7%), 23 (15.4%), eight (5.3%), and three (2%) patients received postoperative chemotherapy, chemoradiation, radiotherapy, and brachytherapy, respectively. Overall, 11 (7.3%) patients developed recurrence. The estimated 5-year disease-free survival of the patients was 90.9%. By multivariate analysis, two factors, age of less than 35 years old and a non squamous histology, were significantly independent prognostic. Eight (5.3%) patients experienced treatment-related complications.CONCLUSION:
Node-negative cervical cancer patients with DSI and/or LVSI had excellent clinical outcomes. Young age and non-squamous histology are significant independent prognostic factors.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Prognosis
/
Aged
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Female
/
Humans
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Carcinoma, Squamous Cell
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Uterine Cervical Neoplasms
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Survival Rate
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Retrospective Studies
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Chemotherapy, Adjuvant
/
Radiotherapy, Adjuvant
Type of study:
Observational study
/
Prognostic study
Language:
English
Year:
2006
Type:
Article
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